2nd October 2019

independent

16

When was AZT discovered?

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In March 1987, when AZT was available on prescription for the first time, almost everyone with Aids wanted to take it, as did many who had tested positive for HIV. One of these was Michael Cottrell, a gay Englishman. He had tested positive for HIV in 1985 at the age of 22.

Likewise, when was AZT introduced?

1996 was a definitive year, certainly, but HAART's development began in earnest nearly a decade before, with the fast-tracked FDA approval of azidothymidine, aka AZT or Retrovir, on March 20, 1987.

What are the side effects of AZT?

The commonest side-effects of zidovudine are nausea, vomiting, headache, dizziness, fatigue, weakness and muscle pain. These often occur in the early weeks of treatment. Medicines to control nausea and headache can be prescribed before starting zidovudine.

How much is AZT?

On introduction, a full year of the stuff cost $10,000. By 1998, the price had only gone down to around $8,000 per year (see: ?"HIV's Inhuman Cost"), despite the influx of new, effective drugs. Currently, the lifetime treatment cost of an HIV infection is $379,668, according to the CDC.

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When was AZT made?

Researcher Jerome P. Horwitz, 93, created AZT, the first approved treatment for HIV/AIDS. When medical researcher Jerome P. Horwitz first synthesized the chemical compound AZT in the 1960s, he hoped it would be a successful treatment for cancer. At first, he thought he had failed.

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Who discovered azidothymidine?

Jerome Horwitz, Detroit Researcher Who Discovered AZT, dies at 93. Jerome P. Horwitz, PhD., the Karmanos Cancer Institute researcher who first found AZT while searching for a cancer fighting agent, has died of heart failure in a hospital just outside of his hometown Detroit. He was 93.

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What does the drug AZT stand for?

Zidovudine (AZT, Retrovir) is an anti-HIV drug that reduces the amount of virus in the body. Anti-HIV drugs such as zidovudine slow down or prevent damage to the immune system, and reduce the risk of developing AIDS-related illnesses.

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How does AZT work in the body?

AZT belongs to a group of drugs called nucleoside analogues. AZT interferes with an enzyme called reverse transcriptase (RT), which is used by HIV-infected cells to make new viruses. Since AZT inhibits, or reduces the activity of this enzyme, this drug causes HIV-infected cells to produce fewer viruses.

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What is the full form of AZT?

This is because the active compound of AZT, known as zidovudine 5-triphosphate, has a high affinity (attraction) for an enzyme called reverse transcriptase, which is used by retroviruses such as HIV to replicate viral single-stranded RNA (ribonucleic acid) into proviral double-stranded DNA (deoxyribonucleic acid).

6

What is Dallas Buyers Club based on a true story?

Briefly: “Dallas Buyers Club”—based on a true story— is about Woodroof, a homophobic womanizer who, after contracting AIDS thanks to a variety of drug-and-sex-related behavior, is stunned to find that the medicine the US government is pushing is no good for him and goes about setting up a “buyers club” for drugs from

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How many pounds did Matthew mcconaughey lose weight?

After dropping 38 pounds to play a man diagnosed with HIV/AIDS in The Dallas Buyer's Club, McConaughey opened up about how he dropped the weight, and revealed the meal he can't wait to sink his teeth into once shooting on the film is complete.

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Who was the real rayon in Dallas Buyers Club?

Rayon in particular was created as a character to give Ron a dramatic challenge to his prejudices while facing disease, Borten told me. The real Woodroof didn't have any particular Rayon in his life, but he was, in fact, deeply changed by his diagnosis and his subsequent work with the Dallas Buyers Club.

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Who is rayon in Dallas Buyers Club?

Jared Leto as Rayon, a fictional trans woman with HIV who helps Woodroof. To accurately portray his role, Leto lost 30 pounds (13 kilograms), shaved his eyebrows and waxed his entire body. He stated the portrayal was grounded in his meeting transgender people while researching the role.

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What year is The Dallas Buyers Club set in?

1985

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Who played rayon in The Dallas Buyers Club?

Jared Leto's

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What is ZDV?

Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS.

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What does acyclovir inhibit?

The guanosine depicted in this specific image is used for RNA synthesis but acyclovir inhibits the synthesis of DNA synthesis. One of the most often used antiviral drugs that works with the described mechanism is acyclovir (aciclovir), a guanosine analogue.

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How many days should you take acyclovir?

It is usually taken with or without food two to five times a day for 5 to 10 days, starting as soon as possible after your symptoms begin. When acyclovir is used to prevent outbreaks of genital herpes, it is usually taken two to five times a day for up to 12 months. Take acyclovir at around the same times every day.

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Is acyclovir and valacyclovir the same thing?

Valtrex is used to treat a variety of herpes viruses, including genital herpes, shingles and cold sores. While Valtrex does not cure herpes, the once-daily treatment does help decrease the occurrence of regular outbreaks. Acyclovir is used for many of the same reasons as Valtrex.

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What is the generic name for valacyclovir?

Valtrex (valacyclovir) is an antiviral medication used to treat infections with: herpes zoster (shingles), herpes simplex genitalis (genital herpes), and herpes labialis (cold sores).

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Is acyclovir and famciclovir the same?

It stops the spread of herpes virus in the body by preventing the replication of viral DNA that is necessary for viruses to multiply. Other drugs in the same class include acyclovir (Zovirax) and valacyclovir (Valtrex). Famciclovir is actually a "prodrug," that is, not active directly against viruses.

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What are the side effects of taking famciclovir?

Less serious side effects may include:

nausea, gas, stomach pain;
diarrhea,
headache, tired feeling;
dizziness, sleepiness;
mild itching or skin rash; or.
numbness or tingly feeling.

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What is famciclovir 500 mg used for?

It slows the growth and spread of the herpes virus so that the body can fight off the infection. Famciclovir will not cure herpes, but it can lessen the symptoms of the infections. Famciclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles.

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