What molecules are produced by the oxidation of pyruvate?

Kkhanacademy

Updated: 21st October 2019

Pyruvate oxidation steps
  • A carboxyl group is removed from pyruvate and released as carbon dioxide.
  • The two-carbon molecule from the first step is oxidized, and NAD+ accepts the electrons to form NADH.
  • The oxidized two-carbon molecule, an acetyl group, is attached to Coenzyme A to form acetyl CoA.

Likewise, what are the products of the oxidation of pyruvate?

So essentially your cells are converting pyruvate into carbon dioxide using two different oxidation steps. During the first oxidation, one pyruvate will be converted into a molecule of acetyl CoA. Acetyl CoA is a product of sugar broken down which will be used in the second oxidation step.

How many ATP molecules are produced in pyruvate oxidation?

The net gain of high-energy compounds from one cycle is 3 NADH, 1 FADH2, and 1 GTP; the GTP may subsequently be used to produce ATP. Thus, the total yield from 1 glucose molecule (2 pyruvate molecules) is 6 NADH, 2 FADH2, and 2 ATP.

Where does the oxidation of pyruvate occur?

Yes, pyruvate oxidation happens in the mitochondrial matrix of eukaryotic cells. As soon as pyruvate enters the mitochondrial matrix in eukaryotes, it is oxidatively decarboxylated (with the help of the enzyme Pyruvate DeHydrogenase, PDH) to form Acetyl CoA (which is then free to act as a substrate in the Krebs cycle).
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