What medications should not be taken with grapefruit?

Don't drink grapefruit juice if you're taking any of these medications, unless advised to by your doctor:
  • Some statins (cholesterol-lowering drugs): lovastatin (Mevacor), atorvastatin (Lipitor), simvastatin (Zocor, Vytorin).
  • Antihistamines: fexofenadine (Allegra)
A.

Can Grapefruit lower your blood pressure?

There is detailed information in our Guide to Grapefruit Interactions. Israeli researchers have found that red grapefruit not only lowers blood pressure but also cholesterol and triglycerides (American Journal of Hypertension, October 2005; Journal of Agricultural and Food Chemistry, March 8, 2006).
  • Are apples good for high blood pressure?

    In fact, research has confirmed that the OPC quercetin is a natural supplement to lower blood pressure. Two of the most quercetin-rich foods that lower high blood pressure are apples and onions. For best medicinal results, you should eat onions raw—cooked onions don't have the same effect.
  • How does grapefruit affect blood pressure?

    Statins are medicines that lower your cholesterol. Grapefruit or grapefruit juice affects some statins. Do not drink grapefruit juice if you're taking simvastatin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.
  • How can you tell if your blood pressure is high during pregnancy?

    Besides high blood pressure, other signs and symptoms of preeclampsia include:
    • Excess protein in your urine (proteinuria) or additional signs of kidney problems.
    • Severe headaches.
    • Changes in vision, including temporary loss of vision, blurred vision or light sensitivity.
B.

Can you eat grapefruit while taking blood pressure medicine?

Eating grapefruit or drinking grapefruit juice can cause some medicines to enter your body faster. This makes it more likely that you will have side effects from the medicine. Interactions can happen up to three days after eating or drinking grapefruit.
  • Which drugs interact with grapefruit?

    Drugs affected by grapefruit juice
    Drug classMajor Interactions
    Statins (HMG-CoA reductase inhibitors)simvastatin (Zocor) lovastatin (Mevacor)
    Cough Suppressant/NMDA Antagonistdextromethorphan
    Erectile dysfunction drugs
    HIV protease inhibitors
  • Can I eat grapefruit while taking levothyroxine?

    Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its bioavailability. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small.
  • What is the effect of grapefruit on medication?

    The authors report that grapefruit, grapefruit juice, and some other citrus fruit, including Seville oranges, limes and pomelos, contain a class of chemical called furanocoumarins. Furanocoumarins inhibit an enzyme, cytochrome P450 3A4, that is responsible for the inactivation of approximately half of all drugs.
C.

What medicines do grapefruit interfere with?

Grapefruit Juice and Some Drugs Don't Mix
  • Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin).
  • Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine).
  • Some organ-transplant rejection drugs, such as Sandimmune and Neoral (both cyclosporine).
  • Is grapefruit good for losing weight?

    Grapefruit can be part of a healthy weight loss diet because it's nutritious, not because of any mysterious fat-burning properties. A half grapefruit or a glass of grapefruit juice before meals may help fill you up, so you'll eat fewer calories at meals and potentially lose weight.
  • Why can't you eat grapefruit when taking a statin?

    Grapefruit contains a chemical that interferes with your body's ability to break down or metabolize certain statin medications. When statin takers eat large amounts of grapefruit, the level of statins in their blood can increase, raising the possibility of side effects.
  • Can I eat grapefruit while taking levothyroxine?

    Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its bioavailability. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small.

Updated: 26th September 2018

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