What is THF stand for?
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- Tetrahydrofuran (THF) is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity.
- For example, titanium tetrachloride is a yellow liquid at room temperature. It is so Lewis acidic that it reacts with moisture in the air, undergoing a reaction that generates HCl gas in the form of white smoke. Tetrahydrofuran (or THF), a mild Lewis base, is a colourless liquid.
- q Diethyl ether is an especially good solvent for the formation of Grignard reagents because ethers are non-acidic (aprotic). Water or alcohols would protonate and thus destroy the Grignard reagent, because the Grignard carbon is highly nucleophilic. This would form a hydrocarbon.
- The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent.
- Chloroform is a slightly polar compound. But it cannot make any strong bond (like hydrogen bond) with water. Due to lack of strong interaction with water its solubility in water is very less. Solubility of chloroform in water is 0.8g/100mL at 20oC.
- Functions. Tetrahydrofolic acid is a cofactor in many reactions, especially in the synthesis (or anabolism) of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.
THF is a polar solvent and monomer that is easily absorbed by all routes of exposure. The acute toxicity of THF is low to moderate by all routes. Irreversible corrosive damage to the eye can result from direct contact. However, THF is neither a skin irritant, nor sensitizer.
- The SN2 reaction is concerted. That is, the SN2 occurs in one step, and both the nucleophile and substrate are involved in the rate determining step. Therefore the rate is dependent on both the concentration of substrate and that of the nucleophile. The SN1 reaction proceeds stepwise.
- The SN1 reaction is a substitution reaction in organic chemistry. "SN" stands for nucleophilic substitution and the "1" represents the fact that the rate-determining step is unimolecular. Thus, the rate equation is often shown as having first-order dependence on electrophile and zero-order dependence on nucleophile.
- A nucleophile is a molecule that forms a bond with its reaction partner (the electrophile) by donating both electrons for that bond. Nucleophiles are Lewis bases. As you've seen, hydroxide is an example of nucleophile that adds to carbon dioxide.
Updated: 2nd October 2019