What is the mechanism of blood clotting?
It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along with deposition and maturation of fibrin.
Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair.
- A platelet plug is formed, and the external bleeding stops. Next, small molecules, called clotting factors, cause strands of blood-borne materials, called fibrin, to stick together and seal the inside of the wound. Eventually, the cut blood vessel heals and the blood clot dissolves after a few days.
- Coagulation is a complex process by which the blood forms clots to block and then heal a lesion/wound/cut and stop the bleeding. It is a crucial part of hemostasis - stopping blood loss from damaged blood vessels. Primary hemostasis - when the platelets gather at the site of an injury to plug (block) it.
- In addition, test tubes used for laboratory blood tests will have chemicals added to stop blood clotting. Apart from heparin, most of these chemicals work by binding calcium ions, preventing the coagulation proteins from using them.
A blood clot is a gel-like mass formed by platelets and fibrin in the blood to stop bleeding. There are a variety of risk factors and illness that can lead to blood clot formation. Risk factors of blood clots forming in a vein may include: Prolonged immobility.
- Blood clots can also form when your blood doesn't flow properly. If it pools in your blood vessels or heart, the platelets are more likely to stick together. Atrial fibrillation and deep vein thrombosis (DVT) are two conditions where slowly moving blood can cause clotting problems.
- If you have swelling in one leg, the area is painful and warm, and symptoms get worse over time, be sure to seek medical care. If you feel a pain in your leg, it's likely a cramp or a pulled muscle. But it could be a much more serious condition: blood clots of deep vein thrombosis, also called DVT.
- The prothrombin time (PT) test measures how well and how long it takes your blood to clot. It normally takes about 25 to 30 seconds. It may take longer if you take blood thinners. Other reasons for abnormal results include hemophilia, liver disease, and malabsorption.
Updated: 26th November 2019