2nd October 2019


What is an ORF and how is it determined?

Once the open reading frame is known the DNA sequence can be translated into its corresponding amino acid sequence. An open reading frame starts with an atg (Met) in most species and ends with a stop codon (taa, tag or tga). For example, the following sequence of DNA can be read in six reading frames.

Similarly, it is asked, what is the reading frame?

In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets. Where these triplets equate to amino acids or stop signals during translation, they are called codons.

How many possible reading frames are there for DNA?

Every nucleotide sequence has six possible reading frames, because each codon (determining one amino acid) consists of a base triplet (3 frames), and there is a complementary strand which could be coding (3 reverse frames).

What is the CDS sequence?

A CoDing Sequence (CDS) is a region of DNA or RNA whose sequence determines the sequence of amino acids in a protein. It should not be mixed up with an Open Reading Frame (ORF), which is a series of DNA codons that does not contain any STOP codons. All CDS are ORFs, but not all ORFs are CDS
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