What is acetylation and methylation?

The bromodomain, found in transcription factors and HATs allows for the preferential recognition of histone tails when they are acetylated at specific lysine residues. 10. Methylation. • It is the introduction of an Methyl functional group to Lysine or Arginine of the histone tail.
A.

What is a histone mark?

A histone modification is a covalent post-translational modification (PTM) to histone proteins which includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers.
  • Why do histones bind tightly to DNA?

    These histones contain many positively charged amino acids (lysine, arginine) making the proteins overall positively charged . DNA is negatively charged due to the phosphate groups in the backbone of DNA. Since opposite charges attract, DNA can bind very well to the histones.
  • Do bacteria cells have histones?

    Nope. Bacteria are prokaryotic (no nucleus). Their DNA is just naked in the cytoplasm. Histones are needed to organize DNA in the nucleus of eukaryotic (true nucleus) cells.
  • Why do histones have a net positive charge?

    Histones are positively charged proteins that wrap up DNA through interactions between their positive charges and the negative charges of DNA. Double-stranded DNA loops around 8 histones twice, forming the nucleosome, which is the building block of chromatin packaging.

Updated: 27th September 2018

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