What does IVIg do to the body?
Your body's immune system normally makes enough antibodies to fight germs that cause infections. IVIg gives you antibodies that your body is not making on its own so you can fight infections. In autoimmune diseases like lupus, the treatment may help your body raise low red-blood-cell counts.
Gammagard Liquid [Immune Globulin Intravenous (Human)] 10% is a preparation of highly purified and concentrated immunoglobulin G (IgG) antibodies used to treat primary immune deficiency, and to reduce the risk of infection in individuals with poorly functioning immune systems such as those with chronic lymphocytic
- Gamma globulins are manufactured in cells of the immune system known as lymphocytes and plasma cells. These globulins, which are known as IgM, IgA, and IgG, represent antibodies.
- Intravenous immunoglobulin (IVIG) contains the pooled immunoglobulin G (IgG) immunoglobulins from the plasma of approximately a thousand or more blood donors. Initially, immune globulin products were administered by intramuscular injection. The image below is a schematic representation of an immunoglobulin G molecule.
- What is IVIG or Intravenous Immunoglobulin? IVIG, also called gamma globulin or antibodies, is a highly purified blood product preparation that is derived from large pools of plasma donors. Plasma from approximately 1,000 to 10,000 persons is present in each unit or “lot” of IVIG therapy.
An immunoglobulin test measures the level of certain immunoglobulins, or antibodies, in the blood. Antibodies are proteins made by the immune system to fight antigens, such as bacteria, viruses, and toxins. The body makes different immunoglobulins to combat different antigens.
- Immunoglobulin A (IgA), as the principal antibody class in the secretions that bathe these mucosal surfaces, acts as an important first line of defence. IgA, also an important serum immunoglobulin, mediates a variety of protective functions through interaction with specific receptors and immune mediators.
- Access the links below for each of the five primary classes to view their properties:
- IgA (immunoglobin A)
- IgD (immunoglobin D)
- IgE (immunoglobin E)
- IgG (immunoglobin G)
- IgM (immunoglobin M)
- While IgM is an indicator of a current infection, an IgG indicates a recent or past exposure to the illness. IgM is the first antibody that the body produces in an acute infection. It is approximately six times larger than IgG and is multivalent. This means that it has multiple binding sites.
How does Intravenous Immunoglobulin Therapy (IVIg) work? Your body's immune system normally makes enough antibodies to fight germs that cause infections, but if you have an immune deficiency, your body can't make enough of them. IVIg gives you antibodies that your body can't make on its own so you can fight infections.
- Increased gamma globulin proteins may indicate: Bone marrow cancer called multiple myeloma. Chronic inflammatory disease (for example, rheumatoid arthritis) Overactive immune system (hyperimmunization)
- SCIg Therapy involves receiving subcutaneous immunoglobulin through a subcutaneous (beneath the skin) infusion. SCIg infusions are given by slowly injecting the immunoglobulin into the fatty tissue (subcutaneous layer) just underneath the skin.
- Hizentra should be administered subcutaneously only. Do not administer intravenously. Hizentra can be dosed daily up to every 2 weeks, using an infusion pump and small needle(s).
Updated: 2nd November 2019