2nd October 2019


What does intrinsic and extrinsic pathway mean?

extrinsic pathway of coagulation. the mechanism that produces fibrin after tissue injury, beginning with formation of an activated complex between tissue factor and activated factor VII and leading to activation of factor X, which induces the reactions of the common pathway of coagulation.

Also asked, what is intrinsic and extrinsic pathway of coagulation?

The fibrin proteins stick together forming a clot. The clotting cascade occurs through two separate pathways that interact, the intrinsic and the extrinsic pathway. Extrinsic Pathway. The extrinsic pathway is activated by external trauma that causes blood to escape from the vascular system.

What are the factors of the intrinsic pathway?

The tissue factor and contact activation pathways both activate the "final common pathway" of factor X, thrombin and fibrin.
  • Tissue factor pathway (extrinsic)
  • Contact activation pathway (intrinsic)
  • Final common pathway.
  • Calcium and phospholipid.
  • Vitamin K.
  • Protein C.
  • Antithrombin.
  • Tissue factor pathway inhibitor (TFPI)

What starts the extrinsic pathway of blood clotting?

The extrinsic pathway of blood coagulation. Upon the introduction of cells, particularly crushed or injured tissue, blood coagulation is activated and a fibrin clot is rapidly formed. The pathway of blood coagulation activated by tissue factor, a protein extrinsic to blood, is known as the extrinsic pathway (Figure 1).
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