What does elevated CRP and ESR mean?
The erythrocyte sedimentation rate (ESR or sed rate) and C-reactive protein (CRP) are among the oldest laboratory tests still in use. 1-3. Both bloods tests are used to detect inflammation in the body. 4-6. Inflammation can present as either acute (ie, from injury or infection) or chronic.
In oncology, a high ESR has been found to correlate with overall poor prognosis for various types of cancer, including Hodgkin's disease, gastric carcinoma, renal cell carcinoma, chronic lymphocytic leukemia, breast cancer, colorectal cancer and prostate cancer.3,14–16 In patients with solid tumors, a sedimentation
- The frequency of an ESR greater than or equal to 100 in these diagnostic groups was infection (28%), malignancy (44%), connective tissue disease (71%), renal disease (30%) and liver disease (24%). Pneumonia was the commonest infection diagnosed and the commonest cause of a markedly elevated ESR.
- Polymyalgia rheumatica (PMR) is an autoimmune disease that causes an inflammatory reaction affecting the lining of joints, especially the shoulders and hips, and sometimes the arteries and some major branches of the aorta.
- Fatal renal failure in polymyalgia rheumatica caused by disseminated giant cell arteritis. A 62-year-old man with classical signs of polymyalgia rheumatica for one year suddenly developed fatal renal failure, despite treatment with steroids.
Results from your sed rate test will be reported in the distance in millimeters (mm) that red blood cells have descended in one hour (hr). The normal range is 0-22 mm/hr for men and 0-29 mm/hr for women. The upper threshold for a normal sed rate value may vary somewhat from one medical practice to another.
- Your doctor may order an ESR test to help detect inflammation in your body. This can be useful in diagnosing conditions that cause inflammation, such as autoimmune diseases, cancers, and infections. An ESR test can monitor inflammatory conditions, such as rheumatoid arthritis or systemic lupus erythematosus.
- High sedimentation rates may be caused by: Autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis. Infection, such as pneumonia, pelvic inflammatory disease, or appendicitis. Inflammation of joints (such as polymyalgia rheumatica) and blood vessels (such as giant cell arteritis).
- ESR: Abbreviation for erythrocyte sedimentation rate, a blood test that detects and monitors inflammation in the body. It measures the rate at which red blood cells (RBCs) in a test tube separate from blood serum over time, becoming sediment in the bottom of the test tube. Also commonly called the sed rate.
Updated: 4th October 2019