What does Coombs positive mean in newborn?
It means that a blood test, called a Coombs test, or Direct Antibody Test (DAT), was done on your baby and was positive. This test is frequently performed on newborn babies. Usually the blood is taken from the baby's cord while it is attached to the placenta following delivery. Sometimes it is taken from the baby.
Your test is positive if it finds antinuclear antibodies in your blood. A negative result means it found no ANAs. A positive result may mean that you have an autoimmune disease such as lupus. About 95% of people with lupus will test positive for antinuclear antibodies.
- An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
- Your test is positive if it finds antinuclear antibodies in your blood. A negative result means it found no ANAs. A positive result may mean that you have an autoimmune disease such as lupus. About 95% of people with lupus will test positive for antinuclear antibodies.
- Tests used to diagnose an immune disorder include:
- Blood tests. Blood tests can determine if you have normal levels of infection-fighting proteins (immunoglobulin) in your blood and measure the levels of blood cells and immune system cells.
- Prenatal testing.
Indirect Coombs test. A negative test result means that your blood is compatible with the blood you are to receive by transfusion. A negative indirect Coombs test for Rh factor (Rh antibody titer) in a pregnant woman means that she has not developed antibodies against the Rh-positive blood of her baby.
- An abnormal (positive) direct Coombs test means you have antibodies that act against your red blood cells. This may be due to: Autoimmune hemolytic anemia. Chronic lymphocytic leukemia or similar disorder. Blood disease in newborns called erythroblastosis fetalis (also called hemolytic disease of the newborn)
- A negative Coombs test indicates that the fetus is not presently in danger from problems relating to Rh incompatibility. An abnormal (positive) result means that the mother has developed antibodies to the fetal red blood cells and is sensitized.
- ABO incompatibility is a common and generally mild type of haemolytic disease in babies. The term haemolytic disease means that red blood cells are broken down more quickly than usual which can cause jaundice, anaemia and in very severe cases can cause death.
An RBC antibody screen is used to screen an individual's blood for antibodies directed against red blood cell (RBC) antigens other than the A and B antigens. It is performed as part of a "type and screen" whenever a blood transfusion is anticipated or as part of prenatal testing of pregnant women.
- A person with an A positive blood type has antigen A on red cells. Having the presence of A antigen, A positive blood type can accept A+ and A-, along with A and B antigen free blood types O+ and O-. Transfusions with any other blood group can trigger an immune response.
- Rhesus (Rh) factor is an inherited protein found on the surface of red blood cells. If your blood has the protein, you're Rh positive. If your blood lacks the protein, you're Rh negative. Rh positive is the most common blood type.
- Everyone's blood is either Rh-positive or Rh-negative—positive means you have a certain protein (called antigens) on the surface of your red blood cells, and negative means you don't. If you're Rh-negative and baby's RH-positive, then there could be problems.
Updated: 6th October 2019