What are the steps involved in ossification?
Endochondral ossification can be summed into 5 major steps:
- Hypertrophication: Chondrocyte cells grow.
- Calcification: Hardening of hyalin cartilage matrix.
- Cavitation: Chrondrocytes die and leave cavities in the bone.
- Periosteal bud invasion: Nutrients are delivered to the bone via blood vessels, and nerves also enter.
This process occurs primarily in the bones of the skull. In other cases, the mesenchymal cells differentiate into cartilage, and this cartilage is later replaced by bone. The process by which a cartilage intermediate is formed and replaced by bone cells is called endochondral ossification.
- Most of the mutations that cause osteogenesis imperfecta type I occur in the COL1A1 gene. These genetic changes reduce the amount of type I collagen produced in the body, which causes bones to be brittle and to fracture easily.
- Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called osteoblasts. It is synonymous with bone tissue formation. It is a process that occurs during ossification, but not vice versa.
- Endochondral ossification is one of the two essential processes during fetal development of the mammalian skeletal system by which bone tissue is created. Unlike intramembranous ossification, which is the other process by which bone tissue is created, cartilage is present during endochondral ossification.
Bone formation, also called ossification, process by which new bone is produced. The cartilage cells die out and are replaced by osteoblasts clustered in ossification centres. Bone formation proceeds outward from these centres. This replacement of cartilage by bone is known as endochondral ossification.
- A hard outer layer called cortical (compact) bone, which is strong, dense and tough. 2. A spongy inner layer called trabecular (cancellous) bone.
- Like a diet rich in calcium and vitamin D, exercise helps strengthen bones at any age. But proper exercise and diet may not be enough to stop bone loss caused by medical conditions, menopause, or lifestyle choices such as tobacco use and excessive alcohol consumption.
- Bone Growth. Bones grow in length at the epiphyseal plate by a process that is similar to endochondral ossification. The cartilage in the region of the epiphyseal plate next to the epiphysis continues to grow by mitosis. Osteoblasts move in and ossify the matrix to form bone.
As you grow, the cartilage in your bones grows. Over time, it slowly gets replaced by bone with the help of calcium. This process is called ossification. During ossification, layer upon layer of calcium and phosphate salts begin to accumulate on cartilage cells.
- When it comes to building strong bones, there are two key nutrients: calcium and vitamin D. Calcium supports your bones and teeth structure, while vitamin D improves calcium absorption and bone growth. These nutrients are important early in life, but they may also help as you age.
- Muscles are also necessary for movement: They're the masses of tough, elastic tissue that pull our bones when we move. Together, our bones, muscles, and joints — along with tendons, ligaments, and cartilage — form our musculoskeletal system and enable us to do everyday physical activities.
- About 95% of a young woman's peak bone mass is present by age 20, and some overall gains in mass often continue until age 30. The average boy has his fastest rate of growth in height between ages 13 and 14, and stops growing between ages 17 and 18.
Updated: 3rd October 2019