Frank's is made from cayenne peppers, while Tabasco (original variety) is made from Tabasco peppers. In addition, Frank's contains garlic powder and "natural flavor." The result is that Frank's is a much more flavorful sauce, which is why it's the traditional ingredient in buffalo wings.
Subsequently, one may also ask, what is a good substitute for hot sauce?
An easier hot sauce alternative: Cayenne pepper powder or red pepper flakes. For soups, stews, marinades, and other sauces, simply adding a chili pepper heat source may be all you need. Oftentimes recipes call for hot sauce as an easy way to add some spice. The other flavors in the recipe mask the vinegar tang.
Can I use Tabasco instead of Sriracha in a recipe?
Careful using it with lighter recipes as the vinegar can overpower less-heavy foods. Sriracha has vinegar, too, but nowhere near the level of Tabasco. It's not a main flavor player in the sauce. Instead the chilies and garlic are the main flavors here.