Hereditary Spastic Paraplegia (HSP) is a group of rare, inherited neurological disorders. Their primary symptoms are progressive spasticity and weakness of the leg and hip muscles. Researchers estimate that some 30 different types of HSP exist; the genetic causes are known for eleven.
Is HSP a disease?
Henoch-Schonlein purpura (HSP) is a disease involving inflammation of small blood vessels. It most commonly occurs in children. The inflammation causes blood vessels in the skin, intestines, kidneys, and joints to start leaking.
Henoch-Schönlein purpura (HSP) is an autoimmune disease (the immune system attacks the body). In the case of HSP, the small blood vessels in the skin become inflamed (a condition called vasculitis) and start leaking red blood cells, which causes a purplish, bruise-like rash on the legs, buttocks, and arms.
In about half of children with HSP, the kidneys are affected. The tiny blood vessels in the kidneys, which filter blood to remove extra water, salt and waste into the urine, become inflamed. This causes the kidneys to 'leak' blood cells and proteins into urine. This is sometimes called HSP nephritis.
HSP is usually self-limited. Therefore, treatment is not indicated in all cases, and full recovery is the rule. HSP is more common in children than adults, but has a tendency to be more severe when it occurs in adults. In a small minority of cases, HSP can cause severe kidney or bowel disease.
Infantile-onset ascending hereditary spastic paralysis is one of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are characterized by progressive muscle stiffness (spasticity) and eventual paralysis of the lower limbs (paraplegia).
Spasticity is a side effect of paralysis that varies from mild muscle stiffness to severe, uncontrollable leg movements. Generally, doctors now call conditions of extreme muscle tension spastic hypertonia (SH). It may occur in association with spinal cord injury, multiple sclerosis, cerebral palsy, or brain trauma.
High sensitivity is an inherited trait. High sensitivity is considered a “normal” trait, not a disease or a disorder. Most HSPs are introverts (about 70%), but around 30% are extroverts.
Approach Considerations. Currently, no specific treatment exists to prevent, retard, or reverse progressive disability in patients with hereditary spastic paraplegia (HSP). Nonetheless, treatment approaches used for chronic paraplegia from other causes are useful.
Definition. Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs.
Paraparesis caused by a viral infection is called tropical spastic paraparesis (TSP). Symptoms can begin long after the original infection, sometimes decades after. TSP affects the spinal cord, compromises the immune system, and can cause muscle weakness and loss of skin sensation in both legs.
Paraparesis (paraplegia), tetraparesis (tetraplegia), urinary/fecal incontinence. Spinal cord diseases. Paraparesis (paraplegia) refers to partial (-paresis) or complete (-plegia) loss of voluntary motor function in the pelvic limbs. Similar involvement of all four limbs is termed tetraparesis (tetraplegia).
Hereditary spastic paraparesis (HSP) is a clinically and genetically heterogeneous neurodegenerative disorder characterised by progressive lower limb spasticity and weakness. This study was prompted by the diagnosis of multiple sclerosis (MS) in two sisters from a large pedigree with hereditary spastic paraparesis.
Many people with multiple sclerosis have stiff muscles and spasms, a condition called spasticity. It can feel like a muscle tightening, or it can be very painful. Spasticity also can make you ache or feel tight in and around your joints and low back.
- Physical exercise and stretching. Stretching helps maintain full range of motion and prevent permanent muscle shortening.
- Braces. Braces can hold a muscle in a normal position to keep it from contracting.
- Intrathecal baclofen therapy (ITB)
- Oral Medications.
Most nurses do not recognize a contracture until it limits joint movement to 45 degrees. Reversing a contracture at this point often takes months but can take years. Most contractures can be reversed if detected before the joint is immobilized completely. Contractures occlude the capillaries in the joint.
Symptoms that often occur with MS spasms and spasticity include pain, weakness and clonus. Spasticity and spasms are not always painful. If there is pain it may feel like a pulling or tugging of the muscles, particularly around joints, or a long lasting episode of cramp.
MS hug. The MS hug is a symptom of multiple sclerosis where you feel as if you have a tight band around your chest or ribs or it can be pressure on just one side of your torso. Some people find that it is painful to breathe. The feeling can range from annoying to very painful.
Common early signs of multiple sclerosis (MS) include:
- vision problems.
- tingling and numbness.
- pains and spasms.
- weakness or fatigue.
- balance problems or dizziness.
- bladder issues.
- sexual dysfunction.
- cognitive problems.
It is a life sentence, however, meaning that there is no cure—although there are plenty of treatments to slow MS down and reduce symptoms. "We think of it as a chronic disease that can be managed, but there are a small percentage of people with severe MS who will die from complications."
MS is more common in individuals of northern European descent. Women are more than twice as likely to develop multiple sclerosis as men. Multiple sclerosis usually affects people between the ages of 20 and 50 years, and the average age of onset is approximately 34 years.