How serious is stage 4 kidney disease?
A person with stage 4 chronic kidney disease (CKD) has advanced kidney damage with a severe decrease in the glomerular filtration rate (GFR) to 15-30 ml/min. It is likely someone with stage 4 CKD will need dialysis or a kidney transplant in the near future.
Stage 5 CKD. A person with Stage 5 CKD has end stage renal disease (ESRD) with a GFR of 15 ml/min or less. At this advanced stage of kidney disease the kidneys have lost nearly all their ability to do their job effectively, and eventually dialysis or a kidney transplant is needed to live.
- As chronic kidney disease progresses to end-stage renal disease, signs and symptoms might include:
- Loss of appetite.
- Fatigue and weakness.
- Sleep problems.
- Changes in how much you urinate.
- Decreased mental sharpness.
- Muscle twitches and cramps.
- Your hands or feet may swell. You will feel tired and weak because your body needs clean blood to function properly. Untreated uremia may lead to seizures or coma and will ultimately result in death. If your kidneys stop working completely, you will need to undergo dialysis or kidney transplantation.
- Signs and symptoms of end-stage COPD. End-stage COPD is marked by severe shortness of breath (dyspnea), even when at rest. End-stage COPD also means increased visits to the emergency department or hospitalizations for breathing complications, lung infections, or respiratory failure.
A stable GFR in people with CKD implies stable disease. The first step in the treatment of CKD is to determine the underlying cause. Some causes are reversible, including use of medications that impair kidney function, blockage in the urinary tract, or decreased blood flow to the kidneys.
- Your doctor can do very simple tests to check for kidney disease:
- Measure the level of serum creatinine in your blood to estimate your glomerular filtration rate (GFR)
- Measure the level of protein in your urine (increased levels of protein show your kidneys are not working right)
- Check your blood pressure.
- A person with stage 1 chronic kidney disease (CKD) has kidney damage with a glomerular filtration rate (GFR) at a normal or high level greater than 90 ml/min. There are usually no symptoms to indicate the kidneys are damaged.
- In the United States the two leading causes of kidney failure, also called end stage kidney disease or ESRD, are diabetes (also called Type 2, or adult onset diabetes) and high blood pressure. When these two diseases are controlled by treatment, the associated kidney disease can often be prevented or slowed down.
Updated: 3rd December 2019