MDF is a pain to work with if you have to remodel later or install hardware several times, as the more you drill it, the less sturdy it becomes and begins to flake. It will also split if not pilot hole drilled. MDF does NOT tolerate water well. Water begins to degrade MDF into fine particles, think wet cardboard.
Furthermore, is MDF board moisture resistant?
MDF (Medium Density Fibre) board is a commonly used particle board. Moisture Resistant MDF is used in places with high humidity levels. In comparison to standard MDF, Moisture Resistant MDF (or MR MDF) contains a moisture-repellent resin which gives it a better moisture resistant rating.
Can MDF be sealed?
Make sure to seal these, especially if they have routed details. You can use an acrylic paint sealer or drywall sealer, or you can use glue or oil based primers which will help prevent the edges from swelling. The sealed MDF edge can be sanded when dry, but you should not completely sand through the glue coating.