28th October 2019


Can you damage your DNA?

Ultraviolet and other types of radiation can damage DNA in the form of DNA strand breaks. This involves a cut in one or both DNA strands; double-strand breaks are especially dangerous and can be mutagenic, since they can potentially affect the expression of multiple genes.

Besides, how does proofreading and repair of DNA work?

DNA polymerases are the enzymes that build DNA in cells. During DNA replication (copying), most DNA polymerases can “check their work” with each base that they add. This process is called proofreading. Polymerase uses 3' to 5' exonuclease activity to remove the incorrect T from the 3' end of the new strand.

Why is it important for a cell to repair its DNA?

Most such spontaneous changes in DNA are temporary because they are immediately corrected by a set of processes that are collectively called DNA repair. The importance of DNA repair is evident from the large investment that cells make in DNA repair enzymes.

Can genetic mutations be repaired?

A mutation, which may arise during replication and/or recombination, is a permanent change in the nucleotide sequence of DNA. Damaged DNA can be mutated either by substitution, deletion or insertion of base pairs.
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