Uses in the heart, brain and muscle (but not the liver) Ketone bodies are transported from the liver to other tissues, where acetoacetate and beta-hydroxybutyrate can be reconverted to acetyl-CoA to produce reducing equivalents (NADH and FADH2), via the citric acid cycle.
In this way, what is fuel for the brain?
Fatty acids do not serve as fuel for the brain, because they are bound to albumin in plasma and so do not traverse the blood-brain barrier. In starvation, ketone bodies generated by the liver partly replace glucose as fuel for the brain. Muscle. The major fuels for muscle are glucose, fatty acids, and ketone bodies.
Is Prolonged ketosis harmful?
In fact, it is the leading cause of death of people with diabetes who are under 24 years of age. However, many experts say ketosis itself is not necessarily harmful. Some studies, in fact, suggest that a ketogenic diet is safe for significantly overweight or obese people.
How much sugar does the brain use?
The RDA is based, the ADA says, “on providing adequate glucose as the required fuel for the central nervous system without reliance on glucose production from ingested protein or fat.” Ah! So it's at least 130 grams of glucose per day that our brain needs!