Can metaplasia be reversed?
Gastric intestinal metaplasia can occur after chronic infection with Helicobacter pylori and is considered a precursor of gastric adenocarcinoma. Thus, interventions which can reverse intestinal metaplasia may reduce the incidence of gastric cancer.
Intestinal metaplasia of the stomach as a precancerous stage. Intestinal metaplasia is defined as the appearance of intestinal epithelium in the stomach. Intestinal metaplasia is frequently found in populations with a high incidence of gastric cancer.
- Dysplasia is still a reversible process. However, once the transformation to neoplasia has been made, the process is not reversible. Thus, there is a natural history from metaplasia to dysplasia to neoplasia. This is best evidenced in development of uterine cervix and respiratory tract neoplasms.
- As intestinal metaplasia (IM) of the stomach is a risk factor in developing intestinal-type gastric cancer, the question of reversibility is vital. There is emerging epidemiological evidence that with long term follow up (at least five years after H pylori eradication) IM may be reversible.
- The association of chronic gastritis with intestinal type metaplasia of gastric mucosa has a poor outcome as intestinal metaplasia is regarded as a precancerous lesion. Metaplasia is common in patients with Helicobacter pylori infection and also heavy smokers.
medical Definition of metaplasia. 1 : transformation of one tissue into another. metaplasia of cartilage into bone.
- (a) Immature squamous metaplasia with underlying endocervical crypt. From birth until puberty, the endocervical epithelium is composed of columnar cells and the ectocervical epithelium of native squamous cells. The interface between the two is termed the original squamocolumnar junction.
- Mucous cell metaplasia (MCM), defined by the appearance of mucous cells in airways where mucous cells were not present, is a consistent pathologic characteristic in the peripheral airways of bronchial asthma.
- Gastric metaplasia is a term used to describe the presence of gastric-type mucus-secreting cells in the surface epithe- lium of the duodenum. The disorder is largely restricted to the duodenal bulb and involves the replacement of normal absorptive and goblet cells by gastric foveolar epithelium.
Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is the “breaking point” in the gastric carcinogenesis cascade and does not appear to regress following H. pylori eradication, although the cure of infection may slow its progression.
- Reactive gastropathy refers to the constellation of endoscopic and histologic findings caused by chemical injury to the gastric mucosa. Reactive gastropathy has also been referred to as chemical gastropathy, reflux gastritis, and type C gastritis.
- There are three goals for treating patients with Barrett's esophagus: stop reflux, promote or induce healing or regression of the metaplastic epithelium such that the risk mucosa (intestinal metaplasia) is eliminated, and halt progression to dysplasia and cancer.
- Barrett's esophagus is often diagnosed in people who have long-term gastroesophageal reflux disease (GERD) — a chronic regurgitation of acid from the stomach into the lower esophagus. Barrett's esophagus is associated with an increased risk of developing esophageal cancer.
Updated: 2nd October 2019